Paul Weisz begins this interview by discussing his family background. Because of the political uncertainty of Austria-Hungary in the post World War I period, his family moved to Berlin when he was a young boy. Weisz was educated in the Gymnasium, where he was exposed to basic science and developed an interest in physics and chemistry. His father further encouraged him to pursue the sciences, and Weisz remembers building small radios. Weisz attended the Technical University in Berlin and spent his free time in the laboratory of Wolfgang Kohlhoerster at the Institute of Cosmic Radiation Research. There, he worked on Geiger counter instrumentation and cosmic ray measurements. Because of Hitler's rise to power, Weisz decided to come to the United States and arranged an exchange program with Auburn University. He earned his BS in physics from Auburn in 1940 and accepted a research position at the Bartol Research Foundation in Pennsylvania. There, Weisz worked on radiation counting and projects relating to the National Research Defense Council. After gaining clearance to do classified work, he moved to the MIT Radiation Laboratory where he helped to develop a long range navigation trainer (Loran). Weisz returned to Bartol, but soon decided to move away from cosmic ray research. He accepted a position with Mobil Corporation, where he worked on catalysis and cracking catalysts. In the 1950s, Weisz began to investigate zeolites and shape selective catalysis. In 1966, he completed his ScD at the Eidgenossische Technische Hochschule in Zürich, where he had worked with Heinrich Zollinger on dye chemistry. Weisz concludes the interview by discussing innovation in industry, the importance of interdisciplinary thinking, and his later work on Alzheimer's Disease and angiogenesis.