Harold Scheraga starts this interview by recalling his childhood in Monticello, New York and then in Brooklyn, where he attended Brooklyn Boys High School. There he was attracted to Latin and mathematics. Scheraga decided to concentrate on chemistry only when he began attending the City College of New York. In the late thirties, CCNY graduates met some difficulties when trying to continue to graduate school. However, Scheraga was offered a place at Duke University, where the chemistry department was chaired by Paul Gross, himself a CCNY graduate. Along with his graduate research on the Kerr effect, Scheraga contributed to the wartime projects on the frangible bullet and on gas-phase halogenation. Influenced in part by the Cohn and Edsall book Peptides, Amino-Acids and Proteins, Scheraga consolidated his growing interest in biochemical areas by a postdoctoral year at Harvard. From there, he was appointed as an instructor in the chemistry department at Cornell, where he has spent the rest of his career, including a period (1960-1967) as chairman. During the 1970s, he was also a visiting professor at the Weizmann Institute. In the second part of his interview with Bohning, Scheraga describes the development of his research activities He first goes into the hydrodynamic properties of polymer solutions, which then led to his extensive work on protein structure and function. Scheraga also recounts his achievements as departmental chairman, with the construction of the new chemistry building and the appointment of new faculty. International collaboration has always been important to Scheraga, and he details his sabbaticals at the Carlsberg laboratory and his later association with the Weizmann Institute.