Antony Rosen grew up in South Africa, the middle child of three. His great-grandparents had migrated there from Russia, but after a couple of generations most of the family had moved on, many settling in the United States. Rosen's father had studied history but sold insurance; his mother was a chemist until she had children. Parental expectations were high (all three children have advanced degrees). Rosen could not avoid experiencing South African apartheid, one result of which was that he attended a Jewish school. He loved the music and liturgy of the Jewish services and went to synagogue every morning; he sang in the boys' choir and led high-holy-day services. For Rosen, science and religion are fundamentally intertwined. Rosen did well in all his high school classwork, but he loved math most. He was not especially inspired until he got to medical school, which, in South Africa, begins right after high school. His teachers influenced his career choice and his coursework in medical school. After finishing medical school he did a rotating internship and then studied for a year in Capetown, South Africa, with Wieland Gevers. Rather than entering military service, he chose to pursue a PhD His PhD application was rejected by the authorities in South Africa, so he accepted a postdoc in the Alan A. Aderem lab at Rockefeller University, though neglected to make living arrangements before he arrived. Rosen adjusted to work in the Aderem lab and to life in New York City, soon meeting Livia A. Casciola, his future wife, who was in Baltimore on a postdoc. He was interested in returning to clinical medicine so he secured an Osler residency and rheumatology fellowship at Johns Hopkins University School of Medicine, and he and Livia were able to marry. She then converted to Judaism and they had another ceremony. Rosen decided to specialize in rheumatology; he accepted a faculty position, and he established his own lab at Johns Hopkins University Medical Center (JHUMC). Throughout the interview Rosen discussed his definition of science; how his brother, Hugh Rosen, influenced his medical school career; the limits of technological expertise in medical science; gender inequality at JHUMC and in science generally; and ethnic and racial issues. He also described his collaboration with his wife in establishing his lab; the meaning of tenure at JHUMC; his funding history and funding in general; the impact of private philanthropy on his lab and research; his teaching, clinical, and administrative responsibilities; the process of writing journal articles; and his lab management style. Rosen's current research centers on apoptosis, and he tells how he became interested in it. He explains what he thinks may be practical applications of his work, and explicates his views on patents; competition and collaboration in science; and the origin of his ideas. He explains how he tries to balance family and career in his typical workday and talks about his interest in food and cooking. He concludes by assessing his professional and personal achievements and goals and discussing his future research plans.