David W. Golde

Born: October 23, 1940 | New York, NY, US
Died: August 9, 2004 | New York, NY, US

Golde's experience in clinical pathology at NIH steered him into hematologic research at UCSF in Martin J. Cline's laboratory. While at UCSF, Golde met several influential scientists who first sparked his interest in hormones. In 1974, Golde left UCSF for the University of California, Los Angeles (UCLA), where he continues his affiliation today as Professor of Medicine, Emeritus. Throughout most of the 1970s, Golde's major field of research was in colony-stimulating factors.

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Interview Details

Interview no.: Oral History 0189
No. of pages: 22
Minutes: 93

Interview Sessions

Audra J. Wolfe
15 December 1999
New York, New York

Abstract of Interview

David Golde begins the interview with a discussion of his early years and education in Bayonne, New Jersey. In high school, Golde developed an interest in medicine, which was stimulated by his biology teacher. He received his BSĀ in chemistry from Fairleigh Dickinson University in 1962. He then attended medical school at McGill University, graduating in 1966. After graduation, Golde completed his internship under the supervision of Dr. Holly (Lloyd) Smith at the University of California, San Francisco (UCSF). Golde joined the faculty at UCSF after completing his residency at the National Institutes of Health. His experience in clinical pathology at NIH steered him into hematologic research at UCSF in Martin J. Cline's laboratory. While at UCSF, Golde met several influential scientists who first sparked his interest in hormones. In 1974, Golde left UCSF for the University of California, Los Angeles (UCLA), where he continues his affiliation today as Professor of Medicine, Emeritus. Throughout most of the 1970s, Golde's major field of research was in colony-stimulating factors. Golde observed cell lines to determine which tissues make colony-stimulating factors. In his laboratory at UCLA, Golde developed a major cell line called KG-1 with H. Phillip Koeffler. The KG-1 cell line was later used to clone alpha interferon. Golde began studying hairy-cell leukemia, researching the cell origins for the disease. Studying cultures of the Mo cell line (named after John Moore, a hairy-cell leukemia patient), Golde's laboratory was the first to purify human GM-CSF (granulocyte-macrophage colony-stimulating factor). With Robert Gallo he discovered a specific strain of retrovirus named HTLV-II, and with his postdoc, Irvin Chen, was the first to clone the HTLV-II virus. Golde concludes the interview with a discussion of the relationship between the biotechnology and the pharmaceutical industries, issues regarding federal transfer of information, and thoughts on his contributions to medicine.

Education

Year Institution Degree Discipline
1962 Fairleigh Dickinson University BS Chemistry
1966 McGill University MD

Professional Experience

University of California School of Medicine, San Francisco

1972 to 1973
Instructor in Medicine
1973 to 1974
Assistant Professor in Medicine

University of California, Los Angeles School of Medicine

1974 to 1975
Assistant Professor of Medicine
1975 to 1979
Associate Professor of Medicine
1979 to 1991
Professor of Medicine
1991
Professor of Medicine Emeritus

Cornell University

1991
Professor of Medicine, Medical College
1992
Professor of Molecular Pharmacology and Therapeutics, Graduate School of Medical Sciences

Memorial Sloan-Kettering Cancer Center

1991
Member
1991 to 1996
Head, Division of Hematologic Oncology
1996
Physician-in-Chief, Memorial Hospital

Honors

Year(s) Award
1965

Alpha Omega Alpha Honor Society, McGill University

1962 to 1966

University Scholar, McGill University

1966

J. Francis Williams Prize in Medicine, McGill University

1986

Outstanding Faculty Research Lecturer, UCLA

1986

MERIT Award, National Institutes of Health

1991

Enid A. Haupt Professor of Hematologic Oncology, Memorial Sloan-Kettering Cancer Center

Table of Contents

Early Years
1

Born in New York City. Growing up in Bayonne, New Jersey. Working as coffee chemist for Maxwell House. Attending medical school at McGill University. Residency at NIH. Important influences for choosing medical field. Holly (Lloyd) Smith. Internship at UCSF.

Early Career
3

Joining faculty at UCSF. Interest in hematology. John Beck. Working in Martin J. Cline's laboratory. Gordon Tompkins. C. H. Li. Leaving UCSF for UCLA. Importance of role models. Research interests in the 1970s. Setting up first normal bone marrow donation program. Theodore Finley.

Research
7

Growing interest in colony-stimulating factors. Uses of colony-stimulating factors. Obtaining patient materials for research. Establishing cell lines. Ethical issues in medical research. Development of KG-1 cell line. H. Phillip Koeffler. Studying hairy-cell leukemia.

Discovery
11

John Moore. Purifying GM-CSF. Judith C. Gasson. Robert C. Gallo. HTLV-I. Irvin S. Y. Chen. Studying retrovirology. Discovery of HTLV-II. Cloning HTLV-II. Molecular biology as an influence on biomedical research.

Conclusion
15

Biotechnology business and the pharmaceutical industry. Consulting for Genetics Institute. Intellectual property rights. Contributions to medical science. Recent research on Vitamin C.

Notes
18
Index
19

About the Interviewer

Audra J. Wolfe