David W. Golde
The information listed below is current as of the date the transcript was finalized.
Abstract of Interview
David Golde begins the interview with a discussion of his early years and education in Bayonne, New Jersey. In high school, Golde developed an interest in medicine, which was stimulated by his biology teacher. He received his BS in chemistry from Fairleigh Dickinson University in 1962. He then attended medical school at McGill University, graduating in 1966. After graduation, Golde completed his internship under the supervision of Dr. Holly (Lloyd) Smith at the University of California, San Francisco (UCSF). Golde joined the faculty at UCSF after completing his residency at the National Institutes of Health. His experience in clinical pathology at NIH steered him into hematologic research at UCSF in Martin J. Cline's laboratory. While at UCSF, Golde met several influential scientists who first sparked his interest in hormones. In 1974, Golde left UCSF for the University of California, Los Angeles (UCLA), where he continues his affiliation today as Professor of Medicine, Emeritus. Throughout most of the 1970s, Golde's major field of research was in colony-stimulating factors. Golde observed cell lines to determine which tissues make colony-stimulating factors. In his laboratory at UCLA, Golde developed a major cell line called KG-1 with H. Phillip Koeffler. The KG-1 cell line was later used to clone alpha interferon. Golde began studying hairy-cell leukemia, researching the cell origins for the disease. Studying cultures of the Mo cell line (named after John Moore, a hairy-cell leukemia patient), Golde's laboratory was the first to purify human GM-CSF (granulocyte-macrophage colony-stimulating factor). With Robert Gallo he discovered a specific strain of retrovirus named HTLV-II, and with his postdoc, Irvin Chen, was the first to clone the HTLV-II virus. Golde concludes the interview with a discussion of the relationship between the biotechnology and the pharmaceutical industries, issues regarding federal transfer of information, and thoughts on his contributions to medicine.
|1962||Fairleigh Dickinson University||BS||Chemistry|
University of California School of Medicine, San Francisco
University of California, Los Angeles School of Medicine
Memorial Sloan-Kettering Cancer Center
Alpha Omega Alpha Honor Society, McGill University
|1962 to 1966||
University Scholar, McGill University
J. Francis Williams Prize in Medicine, McGill University
Outstanding Faculty Research Lecturer, UCLA
MERIT Award, National Institutes of Health
Enid A. Haupt Professor of Hematologic Oncology, Memorial Sloan-Kettering Cancer Center
Table of Contents
Born in New York City. Growing up in Bayonne, New Jersey. Working as coffee chemist for Maxwell House. Attending medical school at McGill University. Residency at NIH. Important influences for choosing medical field. Holly (Lloyd) Smith. Internship at UCSF.
Joining faculty at UCSF. Interest in hematology. John Beck. Working in Martin J. Cline's laboratory. Gordon Tompkins. C. H. Li. Leaving UCSF for UCLA. Importance of role models. Research interests in the 1970s. Setting up first normal bone marrow donation program. Theodore Finley.
Growing interest in colony-stimulating factors. Uses of colony-stimulating factors. Obtaining patient materials for research. Establishing cell lines. Ethical issues in medical research. Development of KG-1 cell line. H. Phillip Koeffler. Studying hairy-cell leukemia.
John Moore. Purifying GM-CSF. Judith C. Gasson. Robert C. Gallo. HTLV-I. Irvin S. Y. Chen. Studying retrovirology. Discovery of HTLV-II. Cloning HTLV-II. Molecular biology as an influence on biomedical research.
Biotechnology business and the pharmaceutical industry. Consulting for Genetics Institute. Intellectual property rights. Contributions to medical science. Recent research on Vitamin C.