George M. Church
The information listed below is current as of the date the transcript was finalized.
Abstract of Interview
George M. Church was born on MacDill Air Force Base in Florida and lived near Tampa, Florida, until high school. He attended both public and Catholic schools, but says both systems were poor. As a result he read a lot, especially science, which he had always liked. When he was about ten he built an analog computer. For high school he was sent to Phillips Academy in Andover, Massachusetts, which he loved and where he throve. Dartmouth College, which was nearby, was beginning timeshare computing, and Church used their computer to teach himself more about computers. When Church entered Duke University he found the computer there less sophisticated than the one he had used while at Andover. He took many classes, usually upper-level or graduate or independent studies (the last requiring that he have keys to the chemistry lab), and finished in two years. He took a summer course in quantum physics at Massachusetts Institute of Technology and then began a job in Sung-Hou Kim's crystallography lab. There he "finally found the intersection of computers and biology." Also during these years he published five papers. In his self-proclaimed unconventional way, Church entered Harvard University's PhD program, doing sequencing in Walter Gilbert's lab, working on polony sequences, and developing some of the earliest sequencers; he introduced multiplexed sequencing. Next he worked a short while at Biogen Research Corporation before taking a postdoc in Gail Martin's lab at the University of California, San Francisco. He left California to be with his future wife, Ting Wu, in Boston, Massachusetts. She became a full professor with tenure at Harvard and eventually entered Church's lab. Needing a job in Boston, Church talked to a friend, Gary Ruvkun, who offered him an assistant professorship in genetics at Harvard Medical School. Church also was made a Howard Hughes Medical Institute Investigator and given a US Department of Energy grant. He has advanced through the ranks and is now Director of the Harvard-MIT Genome Technology Center and Director of the Lipper Center for Computational Genetics, as well as a full professor in genetics. Church's experience at Biogen had inspired an interest in the connection between academia and commerce, and he patented and began to license his work. He continues to be fascinated with the interface between synthesis and sequencing, believing that genomics should be functional and comparative. The Personal Genome Project in his own lab he hopes will help provide affordable personal genomics to many more people.
|1974||Duke University||BA||Zoology and Chemistry|
|1984||Harvard University||PhD||Biochemistry and Molecular Biology|
Biogen Research Corporation
University of California, San Francisco
Harvard Medical School
Harvard/MIT DOE Genome Technology Center
Whitehead Institute for Biomedical Research
National Human Genome Research Institute
The Harvard Wyss Institute
|1974 to 1975||
National Science Foundation Pre-Doctoral Fellowship
|1985 to 1986||
Life Sciences Research Foundation Fellow
|1986 to 1997||
Howard Hughes Medical Institute Investigator
Consumer Genetics Champion & Public Initiative Awards
US Presidential & EPA Green Chemistry Award (LS9)
Triennial International Steven Hoogendijk Award
Franklin Institute Bower Prize for Achievement in Science
Table of Contents
Born in MacDill Air Force Base in Florida. Always liked science. Pond water creatures. Schools not good. Read a lot. Taught himself science. Built analog computer at age of about ten. No interest in religion. Sent to Phillips Academy Andover for high school. Loved Andover. Timesharing computing from Dartmouth College just beginning; Church able to access Dartmouth's files.
Entered Duke University. Majored in zoology and chemistry. Had keys to chemistry lab. Finished in two years. Summer course in quantum physics at Massachusetts Institute of Technology. Job in Sung-Hou Kim's crystallography lab. Intersection of computers and biology perfect for him. Five papers.
Walter Gilbert's lab at Harvard University. Liked sequencing. Getting machine to work in crystallography rotation. Polony sequencing. Multiplexing. Short stint at Biogen Research Corporation. Accepts postdoc at University of California, San Francisco, working in Gail Martin's lab. Interested in interface between academia and commerce. In forefront of genomics. Leaves early to follow future wife, Ting Wu, to Boston, Massachusetts.
Assistant professorship in Genetics; Gary Ruvkun's lab. Howard Hughes Medical Institute. US Department of Energy grant. Wife's career culminating in tenured full professorship at Harvard Medical School. Patents and licensing. Sequencing and synthesis. Functional and comparative genomics. Systems biology a "fantasy. " Applying crystallographic insights into automation and computing to different fields of biology. Founding companies. Connection between research and clinical medicine may lead to personal genomics.
About the Interviewer
David C. Brock is a senior research fellow with the Center for Contemporary History and Policy at the Chemical Heritage Foundation. As a historian of science and technology, he specializes in the history of semiconductor science, technology, and industry; the history of instrumentation; and oral history. Brock has studied the philosophy, sociology, and history of science at Brown University, the University of Edinburgh, and Princeton University.
In the policy arena Brock recently published Patterning the World: The Rise of Chemically Amplified Photoresists, a white-paper case study for the Center’s Studies in Materials Innovation. With Hyungsub Choi he is preparing an analysis of semiconductor technology roadmapping, having presented preliminary results at the 2009 meeting of the Industry Studies Association.