Jerome A. Berson was born in Florida, the older of two children. His father taught Hebrew, and his mother was a milliner and housewife. As a result of the Depression his father struggled to earn a living, and when Berson was about ten the family moved to the Bronx, New York, and then to Long Island, New York. He graduated from high school at fifteen and then rode a Good Humor tricycle to earn some money before beginning City College of New York, chosen primarily for economic reasons. He finished at City a semester early and began working on penicillin at Hoffmann-LaRoche. From there he was drafted into the U. S. Army, in which he worked as a medic in India until the end of World War II. When he was demobilized he married Bella Zevitovsky, whom he had met when they were undergraduates. Knowing he could not progress with only a bachelor's degree, Berson, with the help of the GI Bill, enrolled at Columbia University, where his PhD mentor was William von Eggers Doering. Berson wanted to specialize in the chemistry of natural products, but during these early years Doering began to concentrate on physical organic chemistry. He urged Berson to consider academia as a career and was instrumental in arranging for a postdoctoral fellowship for him with R. B. Woodward at Harvard, where one could soak up the atmosphere of natural products chemistry. Berson credits Woodward and Doering with being two of his prime influences. Learning that jobs were found through the old-boy network, Berson wrote letters to many other universities, receiving only rejections until the University of Southern California (USC) offered him a position. Limited resources and manpower at USC caused him to shift his focus to physical organic chemistry. He attended lively, intense seminars at the University of California, Los Angeles, finding Saul Winstein an enormous influence and eventually "almost a friend." After thirteen years at USC Berson, by now a fully-fledged physical organic chemist, was recruited to the University of Wisconsin, where he stayed for "six of the happiest years of [his] life." At Wisconsin he had funding, facilities, students, and colleagues he could only dream of at USC. His students and he worked hard on exciting, evolving problems; Berson calls it a "seminal time" for him. Thermal and carbocationic rearrangements, and the role of orbital symmetry in chemical reactions, were the focus of his laboratory during this period. While at Wisconsin, Berson had taken note of Erich Hückel's work, which with Hund's Rule provided continuing themes in his thinking and research. Yale University then recruited Berson. The personal reasons he chose to move to Yale included having family nearby and being close to New York City's cultural attractions. Professionally, he noted that Wisconsin's chemistry department, because of its sheer size, was unwieldy to administrate easily as a unit and hence had been divided into sub-units (organic, inorganic, physical, theoretical, et cetera). This fragmentation did not favor cross-disciplinary interactions. He believed that he had much yet to learn, and he found many teachers and colleagues at Yale and elsewhere. The Yale period included many new studies, especially on non-Kekulé molecules. Throughout the interview Berson discusses his own research; the many important chemists he has worked in collaboration with and learned from, some at Yale and others elsewhere; some of his scientific controversies and their resolutions; the enormous changes permitted by technological advances; funding; the vagaries of research and importance of time and setting for progress. Berson explains his current work in the history and philosophy of chemistry; he concludes his interview with thoughts on the present and future of organic chemistry and physical organic chemistry.