The Pew Charitable Trusts

Rudolph E. Tanzi was born in Cranston, a suburb of Providence, Rhode Island, to parents of Italian descent.  His father, until he suffered a fatal heart attack in his forties, was a baker in a family–run bakery in an Italian American community, and his mother started her own medical transcription business, in which Tanzi’s twin sister, older by five minutes, also worked.  Always interested in music, Tanzi began playing the accordion at a young age but soon switched to organ.  He continued to play, even playing with some famous rock bands when he was a teenager, and now extemporizes his own music. His parents wanted him to be a doctor, and he always understood that he would go to college, in spite of his preference for music.  Luckily, he was also interested in the history of science; in high school he entered and won a number of important science competitions.  He became interested in microbiology, in which he majored at the University of Rochester.  In college he entered the Harry Tabor lab, from the beginning preferring research to medicine. After college he became a technician for James Gusella at Massachusetts General Hospital, helping to identify the Huntington’s chorea gene.  He stayed there for four years, continuing at night to play “gigs” with his band.  Somewhat tired of genetics, he applied to Harvard to study neuroscience.  Work on the chromosome implicated in Down syndrome led him to investigate Alzheimer’s disease.  He cloned and characterized the amyloid protein precursor (APP) gene.  He returned to Gusella’s lab after publishing several papers.  Deciding to remain at Harvard, he has progressed from assistant professor to full professor; he is also the director of the genetics and aging unit at Massachusetts General Hospital.  His research into Alzheimer’s disease has resulted in the search for the amyloid gene and the discovery of the presenilin 1 and 2 genes.  He continues to study the role of alpha-2 macroglobulin (A2M) in Alzheimer’s disease; to seek to identify risk factors for Alzheimer’s disease; and to look for new methods to discover the causes of AD.  He is currently writing a book about Alzheimer’s, a book for the layman.

Alison A. Weiss grew up in Wauwatosa, Wisconsin, a suburb of Milwaukee, the second of six children. Her father was an electrician, her mother a housewife. All six children graduated from college, and four have postgraduate education. Alison has always liked science and math and has always done well in them.

Because of campus chaos at the University of Wisconsin, Weiss chose to attend Washington University in St. Louis, where she worked on bacteria in Simon Silver’s lab. She enjoyed the University, Silver’s lab, her independence, and the work, ultimately staying on as a technician for a three years. Weiss began graduate school in Stanley Falkow’s lab at the University of Washington; soon thereafter the lab moved to Stanford University. Weiss chose to work in pathogenic bacteria because she liked microbiology and wanted find a way to use it to help prevent disease. Her dissertation dealt with Bordetella pertussis, and she cloned a pertussis toxin, partly as a result of a short stint with Douglas Berg who taught her a great deal of genetics and a different way of looking at things.

After two years as a postdoc at University of Virginia (UVA) Weiss and her husband were recruited to UVA’s medical school, Virginia Commonwealth University. Weiss received a good setup package and gradually built up her lab. She keeps her lab somewhat small so that she can keep up with the extensive literature. Her main focus is trying to figure out not just what pathogens do, but why and how. She says that even diphtheria, the simplest disease, is still not understood, and pertussis is much more complicated.

Weiss loves bench work and works at balancing it with her family life. She discusses the funding situation, peer review, and the time and effort one must devote to study sections. Asked about her ten-year plan, she says she is lucky or unlucky enough to have realized all her goals so far, but she suggests she might like to do field work, hoping to improve human health. Weiss explains how the Pew Scholars Program in the Biomedical Sciences money helped her. She ends her interview by describing the personality needed to be a scientist, saying science is an exciting, creative, and rewarding career for someone with patience.

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